¿El consumo BAJO de alcohol podría ser beneficioso para el cerebro?

Descubren que el consumo moderado podría preservar ciertas capacidades cognitivas en personas de mediana edad. Pero advierten que "si no se está bebiendo ahora, no hay razón para comenzar a beber para preservar la función cognitiva. Hay muchas otras formas de prevenir el deterioro cognitivo como ejercicio, lectura, etc."

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“Nuestro estudio revela que el consumo bajo a moderado de alcohol se asoció con una mejor función cognitiva total y mejores resultados en el dominio de la cognición individual para el recuerdo de palabras, el estado mental y el vocabulario entre hombres y mujeres de mediana edad o mayores en los Estados Unidos”, así concluye un estudio científico.

Sin embargo, advierten que esto es solo válido para personas de mediana edad o mayores, y que hay mejores formas de cuidar la capacidad cognitiva (por ejemplo estudiando) que no sea consumir alcohol.

La moderación en el consumo de alcohol

Beber con moderación, manda a decir la ley. Claro, con mucha moderación, en tal caso, los investigadores encontraron que los hombres y mujeres de mediana edad a mayores que bebían con moderación tenían tasas más lentas de deterioro cognitivo.

Algunos estudios anteriores han sugerido que el consumo moderado de alcohol tiene efectos cognitivos beneficiosos; pero otros(tal vez la mayoría) lo han encontrado dañino, puesto que el alcohol es tóxico para el organismo.

En el nuevo estudio científico, evaluaron a los participantes en tres campos: estado mental, memoria de palabras y vocabulario. Allí los investigadores analizaron las habilidades cognitivas de casi 20.000 personas durante un promedio de más de nueve años.

 

Cuánto es un consumo bajo o moderado de alcohol

A los fines del estudio, se entiendo por consumo de alcohol bajo a moderado la ingesta de 8 tragos a la semana o menos para las mujeres y 15 o menos para los hombres.

El trago standard es la unidad que mide la cantidad de alcohol puro que contiene una bebida. Un trago equivale en general a 12 gramos de alcohol puro por copa, y es más o menos lo que contiene un vasito o shot de tequila, una copa de vino por la mitad, o una latita de cerveza.

Es decir, el estudio evalúa el consumo de unas 8 copas de vino por semana, en promedio. En comparación con lo que se toma en esos países, se considera un consumo moderado.

 

Los resultados del estudio científico sobre el consumo bajo de alcohol

En las tres áreas descriptas (estado mental, memoria de palabras y vocabulario) quienes tomaron poco alcohol se desempeñaron mejor en comparación con la abstinencia.

El consumo bajo de alcohol se asoció con una trayectoria de funcionamiento mental más alta y una disminución significativamente más lenta a lo largo de los años. Incluso los ex bebedores mostraron un deterioro mental más lento que las personas que nunca bebieron, dice el estudio publicado en JAMA Network Open,

El estudio se descartaron factores como el tabaquismo, el estado civil, la educación, las enfermedades crónicas y el índice de masa corporal, pero los autores reconocieron que se trataba de un estudio observacional, por lo que no pudo probar causa y efecto. También señalaron que se basaba en auto reportes del consumo de alcohol, que pueden ser poco confiables.

“Beber debe limitarse a niveles moderados”, dijo el autor principal, Ruiyuan Zhang, estudiante de doctorado en la Universidad de Georgia. “Beber en exceso empeora la función cognitiva”, afirma el científico.

El investigador agrega: “Si no está bebiendo ahora, no hay razón para comenzar a beber para preservar la función cognitiva. Hay muchas otras formas de prevenir el deterioro cognitivo: ejercicio, lectura, etc.

 

Estudio científico completo sobre el consumo de alcohol

Para leer el paper o estudio científico completo: zhang_2020_oi_200337

 

June 29, 2020
Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults
Ruiyuan Zhang, MD, MS1; Luqi Shen, MS1; Toni Miles, MD, PhD1; et alYe Shen, PhD1; Jose Cordero, MD, MPH1; Yanling Qi, PhD2; Lirong Liang, PhD3; Changwei Li, MD, PhD, MPH1
Author Affiliations Article Information
JAMA Netw Open. 2020;3(6):e207922. doi:10.1001/jamanetworkopen.2020.7922
Key Points Español 中文 (Chinese)
Question Does an association exist between current low to moderate alcohol drinking and cognitive function trajectories or rates of cognitive decline from middle to older age among US adults?

Findings In this cohort study of 19 887 participants from the Health and Retirement Study, with a mean follow-up of 9.1 years, when compared with never drinking, low to moderate drinking was associated with significantly better trajectories of higher cognition scores for mental status, word recall, and vocabulary and with lower rates of decline in each of these cognition domains.

Meaning Current low to moderate alcohol consumption among middle-aged or older adults may be associated with better total cognitive function.

Abstract
Importance Studies examining the association of low to moderate drinking with various cognitive functions have yielded mixed findings.

Objective To investigate whether associations exist between low to moderate alcohol drinking and cognitive function trajectories or rates of change in cognitive function from middle age to older age among US adults.

Design, Setting, and Participants A prospective cohort study of participants drawn from the Health and Retirement Study (HRS), a nationally representative sample of US adults, with mean (SD) follow-up of 9.1 (3.1) years. In total, 19 887 participants who had their cognitive functions measured in the HRS starting in 1996 through 2008 and who had participated in at least 3 biennial surveys were included. The data analysis was conducted from June to November 2019.

Exposures Alcohol consumption and aging.

Main Outcomes and Measures Trajectories and annual rates of change for the cognitive domains of mental status, word recall, and vocabulary and for the total cognitive score, which was the sum of the mental status and word recall scores. Participants were clustered into 2 cognitive function trajectories for each cognition measure assessed based on their scores at baseline and through at least 3 biennial surveys: a consistently low trajectory (representing low cognitive scores throughout the study period) and a consistently high trajectory (representing high cognitive scores throughout the study period).

Results The mean (SD) age of 19 887 participants was 61.8 (10.2) years, and the majority of the HRS participants were women (11 943 [60.1%]) and of white race/ethnicity (16 950 [85.2%]). Low to moderate drinking (<8 drinks per week for women and <15 drinks per week for men) was significantly associated with a consistently high cognitive function trajectory and a lower rate of cognitive decline. Compared with never drinkers, low to moderate drinkers were less likely to have a consistently low trajectory for total cognitive function (odds ratio [OR], 0.66; 95% CI, 0.59-0.74), mental status (OR, 0.71; 95% CI, 0.63-0.81), word recall (OR, 0.74; 95% CI, 0.69-0.80), and vocabulary (OR, 0.64; 95% CI, 0.56-0.74) (all P < .001). In addition, low to moderate drinking was associated with decreased annual rates of total cognitive function decline (β coefficient, 0.04; 95% CI, 0.02-0.07; P = .002), mental status (β coefficient, 0.02; 95% CI, 0.01-0.03; P = .002), word recall (β coefficient, 0.02; 95% CI, 0.01-0.04; P = .01), and vocabulary (β coefficient, 0.01; 95% CI, 0.00-0.03; P = .08). A significant racial/ethnic difference was observed for trajectories of mental status (P = .02 for interaction), in which low to moderate drinking was associated with lower odds of having a consistently low trajectory for white participants (OR, 0.65; 95% CI, 0.56-0.75) but not for black participants (OR, 1.02; 95% CI, 0.74-1.39). Finally, the dosage of alcohol consumed had a U-shaped association with all cognitive function domains for all participants, with an optimal dose of 10 to 14 drinks per week.

Conclusions and relevance These findings suggested that low to moderate alcohol drinking was associated with better global cognition scores, and these associations appeared stronger for white participants than for black participants. Studies examining the mechanisms underlying the association between alcohol drinking and cognition in middle-aged or older adults are needed.

Introduction
Alcohol misuse is a leading cause of morbidity and mortality.1 Alcohol consumption is associated with a uniformly increased risk of hypertension and stroke, regardless of dose,2 and heavy and binge drinking is associated with a higher risk of cardiovascular disease.3 However, studies have also found that low to moderate alcohol consumption is associated with protective effects against cardiovascular diseases.4-6 Besides its role in physical health, low to moderate alcohol consumption has been shown to play a role in the development of cognitive impairment and dementia, conditions that are highly associated with cardiovascular diseases, although the findings are mixed. Specifically, some studies have reported benefits to cognitive function associated with low to moderate alcohol consumption,7-11 whereas others have found no, minimal, or even adverse effects associated with alcohol consumption.12-15 The Nurses’ Health Study11 followed up with approximately 11 000 participants for 2 years and found that moderate drinkers perform better on general cognitive function and verbal memory tests and have slower rates of decline with time on these 2 cognitive functions compared with nondrinkers. Similarly, a 10-year follow-up study among 7153 British civil servants16 identified a protective association between low alcohol consumption and rates of global cognitive function and executive function decline compared with never drinking among women but not among men. By contrast, the Whitehall II imaging substudy15 followed up with 550 participants for more than 30 years and found that even moderate drinking is associated with cognitive function decline.

Cognitive functions are affected by many factors and vary with time. A single measurement cannot capture all aspects of cognition function and thus decreases the statistical efficiency of identifying potential risk factors.17-19 Using repeated measurements at different follow-up times can produce a more reliable estimate for both interpopulation and intrapopulation variations of cognitive functions.20 Moreover, although cognitive functions may decline with age, this decline is heterogeneous among people in different age groups.21,22 Thus, this heterogeneity should also be considered in studies of cognitive function. A few studies focusing on the association of alcohol drinking with cognitive function decline have taken repeated measurements into account; however, those studies used net follow-up time, instead of age, to calculate the rates of cognitive function decline and did not consider the heterogeneous effects associated with age.8,9,11,15

The present study investigated the association of low to moderate alcohol consumption with cognitive functions by using repeated cognition measurements and evaluated the association of low to moderate alcohol consumption with age-related decline in cognitive function in a nationally representative sample of middle-aged and older US adults.

Methods
Study Population
The present study was a secondary analysis of data from the Health and Retirement Study (HRS), a longitudinal panel study that surveys a nationwide representative sample of about 20 000 middle-aged and older US adults. The HRS participants have been reexamined every 2 years since 1992 (HRS wave 1) to collect their health and economic information.23 The HRS initially used the Telephone Interview for Cognitive Status,24 a brief telephone screening system to assess cognitive functioning. Since 1996 (HRS wave 3), a modification of that survey has been used to measure cognitive functioning.25 For consistency in measurements of the different waves, the present analyses used data from wave 3 (1996) and later. Furthermore, we only included participants who participated in at least 3 biennial surveys. Our study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. This secondary analysis of deidentified data from the HRS was approved by the institutional review board of the University of Georgia at Athens. Written informed consent was obtained from all participants in the original HRS. No one received compensation or was offered any incentive for participating in this study.

Cognitive Function Tests
The HRS used age to determine which cognitive tests would be administered. Specifically, all respondents older than 65 years received a full set of tests in and before 1998 (wave 4); all new respondents received a full set of tests regardless of their age after 1998; and all reinterviewed respondents younger than 65 years received 2 questions self-assessing their memory (present rating and the changes), immediate and delayed recall tests, a backward counting test, and a serial 7s subtraction test in which 7 is subtracted from a given number for 5 trials.25 Because the HRS recruited additional new participants for each wave of the survey, data collected for each participant’s entry into the HRS were treated as the baseline for that participant. The follow-up measurements were defined as measurements of onward waves for each participant.

Cognitive functioning was measured by assessing 3 domains: total word recall, mental status, and vocabulary. Total word recall was scored as the summed results of an immediate word recall test and a delayed word recall test and ranged from 0 to 20, reflecting the number of words that a participant could correctly recall immediately or 5 minutes after they were read a list of 10 words. Mental status was measured using a set of tests that assess knowledge, language, and orientation, with scores ranging from 0 to 15. Vocabulary, also known as crystalized intelligence, represents established knowledge and was tested by assessing the ability of the participants to provide the definitions of 5 given words, with scores ranging from 0 to 10. The total cognition score was calculated as the summed scores of the total word recall results and the mental status test results and ranged from 0 to 35.25,26 Higher cognition scores indicated better cognitive abilities.

Alcohol Drinking and Covariates
Alcohol consumption was assessed using the following questions: “Have you ever drank any alcoholic beverages, such as beer, wine, or liquor?”; “In the last 3 months, on average, how many days per week have you had any alcohol to drink?”; and “In the last 3 months, on the days you drank, about how many drinks did you have?” After wave 3 of the HRS (1996), participants were initially assessed for ever drinking.26 Ever drinkers were further asked for their drinking status in the last 3 months. On the basis of the answers to those questions at baseline, we categorized HRS participants as never drinkers, former drinkers, or current drinkers. Former drinkers were defined as participants who drank alcohol more than 3 months before the baseline interview, and current drinkers were defined as participants who drank alcohol within 3 months before the interview.26 For current drinkers, we calculated the alcohol consumption as the product of the number of days of drinking per week and the number of drinks per day. Current drinkers were then further categorized as low to moderate drinkers or heavy drinkers. Women with 8 or more drinks per week or men with 15 or more drinks per week were categorized as heavy drinkers27; otherwise, current drinkers were defined as low to moderate drinkers. Other covariates included age, sex, race/ethnicity, years of education, marital status, tobacco smoking status, and body mass index. Tobacco smoking status was categorized into 3 groups: never smoker, former smoker, and current smoker based on self-reported responses to these 2 questions: “Have you ever smoked cigarettes?” and “Do you smoke cigarettes now?”

Statistical Analysis
Baseline characteristics for all included participants and by cognitive function trajectories are presented as percentages for categorical variables and mean (SD) values or median values and interquartile ranges (IQRs) for continuous variables. Nonparametric tests, χ2 tests, or t tests were used to compare the distribution of those characteristics by trajectory groups for each cognitive function measure. Data analyses were performed using data from participants with complete observations.

Latent variable mixture modeling implemented using the SAS Proc Traj procedure was used to identify subgroups that shared a similar progression for an outcome over time; more specifically, a similar trajectory for the various cognitive functions tested during follow-up.28,29 We fitted all trajectory models in quadratic form and from a 1-trajectory group up to a 5-trajectory group. The bayesian information criterion and visual assessment in the balance of the number of participants in the trajectory groups were used to select the number of groups that best fit the data. Trajectory analyses were conducted for each cognition domain and for overall cognitive function. When 2 trajectory groups best fit the data, we further assessed the model fit for different forms, with the optimal model having 2 trajectory groups in cubic form for each cognitive function measure.

The annual rate of age-related change for each individual was calculated by regressing cognitive function traits with age using all observations that an individual contributed, and the coefficient of age was treated as the age-related annual rate of change.

Multivariate logistic and linear regressions were used to evaluate associations of alcohol drinking with cognitive function trajectories and age-related annual rate of change, respectively, after controlling for age, sex, race/ethnicity, educational level, marital status, smoking status, and body mass index. The association analyses were also conducted by sex and race/ethnicity. Sex and racial/ethnic differences were evaluated by adding an interaction term, that is, alcohol drinking by sex or alcohol drinking by race/ethnicity, respectively, to the fully adjusted model.

We further assessed the potential nonlinear association between the number of drinks per week and the odds ratio (OR) of being clustered into groups with lower cognitive performance by using a nonparametric method with restricted cubic splines after controlling for the same set of covariates as for the regression model.30 This method used the likelihood ratio method to test the nonlinearity between the model having only a linear association and the model having a linear association and cubic spline terms. Sensitivity analyses were performed after excluding participants with at least 1 chronic disease condition. The analyses were performed from June to November 2019 using SAS, version 9.4 (SAS Institute Inc), and R, version 3.5.1 (The R Foundation). Bonferroni corrections were applied to account for multiple testing, and a 2-side P = .01, correcting for 4 cognition measures, was considered a statistically significant association.

Results
In total, 19 887 people who participated in the HRS between 1996 and 2008 were included in the present study study (eFigure 1 in the Supplement), and their mean (SD) follow-up was 9.1 (3.1) years. Total word recall was measured among all 19 887 HRS participants, mental status and total cognition score were evaluated among 12 683 (63.8%) participants, and vocabulary was assessed for 9931 (49.9%) participants. As shown in Table 1, the mean (SD) age of all study participants was 61.8 (10.2) years. The majority of the HRS participants were female (11 943 [60.1%]) and of white race/ethnicity (16 950 [85.2%]). In total, 10 824 (54.4%) participants were ever drinkers, among which, 3767 (18.9%) were former drinkers and 7057 (35.5%) were current drinkers. Most of the current drinkers (6010 [85.2%]) were low to moderate drinkers. In addition, among all participants, 7813 (39.5%) were former smokers, 3704 (18.7%) were current smokers, and 5596 (28.1%) had a marital status of single or separated. Overall, HRS participants had a mean (SD) of 12.4 (3.1) years of education and were overweight (mean [SD] body mass index calculated as weight in kilograms divided by height in meters squared, 27.3 [5.3]).

For each cognitive function measure, participants were categorized into a consistently low trajectory group (ie, cognitive test scores from baseline through follow-up were consistently low) or a consistently high trajectory group (ie, cognitive test scores from baseline through follow-up were consistently high) (Figure 1; eFigure 2 in the Supplement). Of 12 683 participants, 2972 (23.4%) had a consistently low trajectory for mental status, 9538 of 19 887 (48.0%) for word recall, 2444 of 9931 (24.6%) for vocabulary, and 3619 of 12 683 (28.5%) for total cognitive function score. As shown in Table 1, for each cognitive function measure, compared with participants in the consistently high trajectory group, those with a consistently low trajectory were more likely to be older, black individuals, single or separated, and tobacco smokers, and had fewer years of education and a higher body mass index. However, individuals with consistently low cognitive function results were less likely to be a current or former drinker (Table 1; eTable 1 in the Supplement).

The associations of alcohol consumption and cognitive function trajectories are presented in Table 2. After controlling for all covariates, compared with never drinkers, current low to moderate drinkers were significantly less likely to be associated with consistently low trajectories for total cognitive score (OR, 0.66; 95% CI, 0.59-0.74), mental status (OR, 0.71; 95% CI, 0.63-0.81), word recall 0.74 (95% CI, 0.69-0.80), and vocabulary (OR, 0.64; 95% CI, 0.56-0.74) (all P < .001). Similarly, among former drinkers, ORs for being in the consistently low trajectory group were 0.72 (95% CI, 0.63-0.82) for the total cognitive score, 0.83 (95% CI, 0.72-0.95) for mental status, 0.76 (95% CI, 0.70-0.83) for word recall, and 0.73 (95% CI, 0.63-0.86) for vocabulary. Heavy drinkers had lower odds of being in the consistently low trajectory group only for the vocabulary test (OR, 0.51; 95% CI, 0.37-0.71). Low to moderate drinkers were also significantly associated with the age-related annual rate of change, with effect sizes of 0.04 (95% CI, 0.02-0.07; P = .002) for the total cognition score, 0.02 (95% CI, 0.01-0.03) for mental status, 0.02 (95% CI, 0.01-0.04; P = .01) for word recall, and 0.01 (95% CI, 0.00-0.03; P = .08) for vocabulary (Figure 2; eFigure 3 in the Supplement).

Spline analyses showed significant U-shaped associations between weekly drinking doses and the odds of being in the consistently low trajectory group for all cognitive function domains (eFigure 4 in the Supplement). The weekly drinking dose at the turning points were 12 drinks for the total cognition score, 13 drinks for mental status, 10 drinks for word recall, and 14 drinks for vocabulary. Sensitivity analyses among participants with no chronic disease condition showed that the U-shaped association was still significant for the scores of total word recall (P = .001) and vocabulary (P = .004), but not for mental status (P = .88) or total cognition score (P = .19) (eFigure 5 in the Supplement).

The associations of alcohol drinking and cognitive functions were similar between men and women (eTable 2 in the Supplement) but differed for race/ethnicity. As shown in Table 3, low to moderate drinking was significantly associated with lower odds of having a consistently low trajectory for all 4 cognitive function measures only among white participants. For example, low to moderate drinking was associated with lower odds of having a consistently low mental status trajectory among white participants (OR, 0.65; 95% CI, 0.56-0.75) but not among black participants (OR, 1.02; 95% CI, 0.74-1.39) (P = .02 for interaction). In addition, the magnitude of the associations was stronger among white participants. The P values for the U-shaped associations were lower for white participants than for black participants and for men compared with women (eFigures 6, 7, 8, and 9 in the Supplement).

Discussion
The present study found that low to moderate drinking was associated with consistently high cognitive function trajectories, that is, cognitive test scores at the baseline middle-aged assessment were relatively high and remained high at each subsequent assessment, and a decreased rate of cognitive decline with age for middle-aged or older US adults. Alcohol consumption had a U-shaped relationship with cognitive function scores, with an optimal dosage of 10 to 14 drinks per week for all participants. The association of low to moderate drinking with higher cognitive function trajectories was stronger among white participants than among black participants.

Low to moderate alcohol drinking was associated with protecting cognitive function as assessed by the total cognitive score and the scores of each of the 3 cognition domains tested (mental status, word recall, and vocabulary). We also found that compared with never drinkers, low to moderate drinkers had slower rates of cognitive decline across time for all cognition domains evaluated. The association was strongest for the vocabulary test. These findings are in line with previous research. The Rancho Bernardo Study in southern California31 reported that moderate, regular alcohol drinking was associated with better cognitive function compared with never drinking among community-dwelling adults with a mean age of 73.2 years. The Nurses’ Health Study11 results suggested that up to 1 drink per day was associated with decreased risk of cognitive decline among women aged 70 to 81 years. Our study contributed further evidence that among a nationally representative sample of middle-aged or older adults, low to moderate drinking was associated with the protection of cognitive functions that may decrease with age. The association of low to moderate drinking with cognitive functions varies with age.15,21,22 The Whitehall II study of 550 participants in the UK15 reported that moderate drinkers with a mean age of 43 years were more likely to have hippocampal atrophy, and light drinking did not show a protective association compared with abstinence. However, that study defined moderate drinking as 14 to 21 units per week, which would be categorized as heavy drinking in our study. The association of low to moderate drinking with cognitive function in the younger age group warrants further investigation.

In the present study, although low to moderate drinking was associated with better cognitive functions and slower rates of cognitive decline, the associations between the weekly drinking dose and the various cognitive functions were U-shaped. The optimal alcohol dosage associated with better cognitive function was 10 to 14 drinks per week for all participants. Although the majority of drinkers in the HRS were low to moderate drinkers, 15.0% of white men (median 6; IQR, 2-12), 4.9% of white women (median, 3; IQR, 2-7), 15.7% of black men (median, 6; IQR, 2-10), and 5.6% of black women (median, 4; IQR, 2-6) had more than 14 drinks per week. Public health campaigns are still needed to further reduce alcohol drinking in middle-aged or older US adults, particularly among men. The mechanisms underlying the beneficial association of low to moderate alcohol consumption with cognitive function are unclear. The main hypotheses focus on cerebrovascular and cardiovascular pathways and on brain-derived neurotrophic factor. Several studies have found that low to moderate alcohol consumption is associated with better cardiovascular functions, fewer cardiac events, and longer survival compared with abstainers and heavy drinkers4-6,32; thus, the decreased risk of cognitive impairment has been thought to be associated with alcohol consumption. However, a recent study found that alcohol consumption increases the risk of hypertension and stroke regardless of dose,2 which decreases the likelihood of this potential mechanism. The role of alcohol drinking in cognitive function may be a balance of its beneficial and harmful effects on the cardiovascular system. Among low to moderate drinkers, the beneficial effects may outweigh the harmful effects on the cardiovascular system. Moderate drinking also increases brain-derived neurotrophic factor levels, a key regulator of neuronal plasticity and development, in the dorsal striatum, whereas levels of alcohol consumption leading to intoxication do not alter the mRNA expression levels of this factor.33

Strengths and Limitations
Our study has several strengths. First, we analyzed data from a nationally representative, large sample of middle-aged or older US adults. Thus, findings of our study can be generalized to all middle-aged or older US adults. Second, repeatedly measured cognitive functions with a mean (SD) follow-up of 9.1 (3.1) years were used, which allowed us to estimate both long-term trajectories and age-associated annual rates of change in cognitive functions. Third, we used a group-based trajectory analysis approach to handle repeated measurements of the cognitive functions, which may eliminate random variations caused by a single measurement and thus provide higher accuracy of grouping and estimations.

However, certain limitations should also be acknowledged. First, alcohol consumption was self-reported, which could introduce recall bias that classifies heavy drinkers as low to moderate drinkers because participants tend to underestimate their alcohol consumption.34 Such misclassification would bias our association estimates toward the null, thus reducing statistical power to detect associations between alcohol drinking and cognitive functions. However, despite such a bias, our study still detected significant associations between alcohol consumption and cognitive function; thus, our data were sufficiently robust. Second, very few HRS participants had high weekly alcohol consumption, particularly among women and black participants, limiting the power of our analyses to identify an association of heavy drinking with cognitive function for these groups. Third, alcohol consumption tended to change with time; thus, this change may be associated with other factors that led to a change in cognitive function. Our study did not account for this possibility. Fourth, in the sensitivity analyses among participants with no chronic disease condition at baseline, the U-shaped associations were significant only for word recall and vocabulary, not for mental status and total cognitive score. The U-shaped associations for these latter 2 measures in the main analyses might have been due to confounding by health status. Healthy participants had higher cognitive function scores and might be engaged in more social activities and have higher alcohol consumption, leading to the higher cognitive function scores shown in the tails of the U-shaped plots. However, the study participants were middle-aged or older US adults, and 77.2% of the participants had at least 1 chronic disease condition. Therefore, the association between alcohol drinking and cognitive function may be applicable both to healthy people and to those with a chronic disease. Fifth, because fewer participants had high levels of weekly alcohol drinking, the 95% CIs for the risk of having low cognitive function among these people were wide. Thus, the reliability of the estimates for this group could be low.

Conclusions
Our study suggested that low to moderate drinking was associated with better total cognitive function and better individual cognition domain results for word recall, mental status, and vocabulary among middle-aged or older men and women in the United States. Low to moderate alcohol use was also associated with slower rates of cognitive decline in those domains. These associations were stronger for white participants than for black participants. Furthermore, weekly alcohol consumption had U-shaped relationships with the cognitive functions assessed, with the strongest associations with better cognitive functions at a dosage of 10 to 14 drinks per week for all participants.

Article Information
Accepted for Publication: March 28, 2020.

Published: June 29, 2020. doi:10.1001/jamanetworkopen.2020.7922

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Zhang R et al. JAMA Network Open.

Corresponding Author: Changwei Li, MD, PhD, MPH, Department of Epidemiology and Biostatistics, University of Georgia College of Public Health, B. S. Miller Hall, Room 120, 101 Buck Rd, Athens, GA 30602 (changwei.li@uga.edu).

Author Contributions: Dr Li had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Miles, Cordero, Qi, Li.

Acquisition, analysis, or interpretation of data: Zhang, L. Shen, Y. Shen, Qi, Liang, Li.

Drafting of the manuscript: Zhang, L. Shen.

Critical revision of the manuscript for important intellectual content: Miles, Y. Shen, Cordero, Qi, Liang, Li.

Statistical analysis: Zhang, L. Shen, Y. Shen, Qi, Li.

Administrative, technical, or material support: L. Shen, Miles, Y. Shen, Liang.

Supervision: Miles, Y. Shen, Cordero, Li.

Conflict of Interest Disclosures: None reported.

Funding/Support: The present study is supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award UL1TR002378.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Disclaimer: The content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

References
1.
Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet. 2009;373(9682):2223-2233. doi:10.1016/S0140-6736(09)60746-7PubMedGoogle ScholarCrossref
2.
Millwood IY, Walters RG, Mei XW, et al; China Kadoorie Biobank Collaborative Group. Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China. Lancet. 2019;393(10183):1831-1842. doi:10.1016/S0140-6736(18)31772-0PubMedGoogle ScholarCrossref
3.
Zaridze D, Lewington S, Boroda A, et al. Alcohol and mortality in Russia: prospective observational study of 151,000 adults. Lancet. 2014;383(9927):1465-1473. doi:10.1016/S0140-6736(13)62247-3PubMedGoogle ScholarCrossref
4.
Bell S, Daskalopoulou M, Rapsomaniki E, et al. Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017;356:j909. doi:10.1136/bmj.j909PubMedGoogle ScholarCrossref
5.
Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ. 2011;342:d671. doi:10.1136/bmj.d671PubMedGoogle ScholarCrossref
6.
Wood AM, Kaptoge S, Butterworth AS, et al; Emerging Risk Factors Collaboration/EPIC-CVD/UK Biobank Alcohol Study Group. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies. Lancet. 2018;391(10129):1513-1523. doi:10.1016/S0140-6736(18)30134-XPubMedGoogle ScholarCrossref
7.
Elias PK, Elias MF, D’Agostino RB, Silbershatz H, Wolf PA. Alcohol consumption and cognitive performance in the Framingham Heart Study. Am J Epidemiol. 1999;150(6):580-589. doi:10.1093/oxfordjournals.aje.a010056PubMedGoogle ScholarCrossref
8.
Ganguli M, Vander Bilt J, Saxton JA, Shen C, Dodge HH. Alcohol consumption and cognitive function in late life: a longitudinal community study. Neurology. 2005;65(8):1210-1217. doi:10.1212/01.wnl.0000180520.35181.24PubMedGoogle ScholarCrossref
9.
Kabai P. Alcohol consumption and cognitive decline in early old age. Neurology. 2014;83(5):476. doi:10.1212/01.wnl.0000453101.10188.87PubMedGoogle ScholarCrossref
10.
Mehlig K, Skoog I, Guo X, et al. Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in Goteborg. Am J Epidemiol. 2008;167(6):684-691. doi:10.1093/aje/kwm366PubMedGoogle ScholarCrossref
11.
Stampfer MJ, Kang JH, Chen J, Cherry R, Grodstein F. Effects of moderate alcohol consumption on cognitive function in women. N Engl J Med. 2005;352(3):245-253. doi:10.1056/NEJMoa041152PubMedGoogle ScholarCrossref
12.
Elwood PC, Gallacher JE, Hopkinson CA, et al. Smoking, drinking, and other life style factors and cognitive function in men in the Caerphilly cohort. J Epidemiol Community Health. 1999;53(1):9-14. doi:10.1136/jech.53.1.9PubMedGoogle ScholarCrossref
13.
Gross AL, Rebok GW, Ford DE, et al. Alcohol consumption and domain-specific cognitive function in older adults: longitudinal data from the Johns Hopkins Precursors Study. J Gerontol B Psychol Sci Soc Sci. 2011;66(1):39-47. doi:10.1093/geronb/gbq062PubMedGoogle ScholarCrossref
14.
Herbert LE, Scherr PA, Beckett LA, et al. Relation of smoking and low-to-moderate alcohol consumption to change in cognitive function: a longitudinal study in a defined community of older persons. Am J Epidemiol. 1993;137(8):881-891. doi:10.1093/oxfordjournals.aje.a116749PubMedGoogle ScholarCrossref
15.
Topiwala A, Allan CL, Valkanova V, et al. Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. BMJ. 2017;357:j2353. doi:10.1136/bmj.j2353PubMedGoogle ScholarCrossref
16.
Sabia S, Elbaz A, Britton A, et al. Alcohol consumption and cognitive decline in early old age. Neurology. 2014;82(4):332-339. doi:10.1212/WNL.0000000000000063PubMedGoogle ScholarCrossref
17.
Cagney KA, Lauderdale DS. Education, wealth, and cognitive function in later life. J Gerontol B Psychol Sci Soc Sci. 2002;57(2):163-172. doi:10.1093/geronb/57.2.P163PubMedGoogle ScholarCrossref
18.
Korten AE, Henderson AS, Christensen H, et al. A prospective study of cognitive function in the elderly. Psychol Med. 1997;27(4):919-930. doi:10.1017/S0033291797005217PubMedGoogle ScholarCrossref
19.
Skirbekk V, Loichinger E, Weber D. Variation in cognitive functioning as a refined approach to comparing aging across countries. Proc Natl Acad Sci U S A. 2012;109(3):770-774. doi:10.1073/pnas.1112173109PubMedGoogle ScholarCrossref
20.
Karlamangla AS, Miller-Martinez D, Aneshensel CS, Seeman TE, Wight RG, Chodosh J. Trajectories of cognitive function in late life in the United States: demographic and socioeconomic predictors. Am J Epidemiol. 2009;170(3):331-342. doi:10.1093/aje/kwp154PubMedGoogle ScholarCrossref
21.
Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature. 2010;464(7288):529-535. doi:10.1038/nature08983PubMedGoogle ScholarCrossref
22.
Salthouse TA. When does age-related cognitive decline begin? Neurobiol Aging. 2009;30(4):507-514. doi:10.1016/j.neurobiolaging.2008.09.023PubMedGoogle ScholarCrossref
23.
Sonnega A, Faul JD, Ofstedal MB, Langa KM, Phillips JW, Weir DR. Cohort profile: the Health and Retirement Study (HRS). Int J Epidemiol. 2014;43(2):576-585. doi:10.1093/ije/dyu067PubMedGoogle ScholarCrossref
24.
Brandt J, Spencer M, McSorley P, Folstein MF. Semantic activation and implicit memory in Alzheimer disease. Alzheimer Dis Assoc Disord. 1988;2(2):112-119. doi:10.1097/00002093-198802020-00003PubMedGoogle ScholarCrossref
25.
Ofstedal MB, Fisher GG, Herzog AR. Documentation of Cognitive Functioning Measures in the Health and Retirement Study. HRS Health Working Group; 2005.
26.
RAND Center for the Study of Aging. Social and economic well-being: HRS Longitudinal File 2016 (V1) Documentation. Published May 2019. Accessed May 13, 2020. https://www.rand.org/content/dam/rand/www/external/labor/aging/dataprod/randhrs1992_2016v1.pdf
27.
Centers for Disease Control and Prevention. Alcohol use and your health. Accessed November 14, 2019. https://www.cdc.gov/alcohol/fact-sheets/alcohol-use.htm
28.
Ram N, Grimm KJ. Growth mixture modeling: a method for identifying differences in longitudinal change among unobserved groups. Int J Behav Dev. 2009;33(6):565-576. doi:10.1177/0165025409343765PubMedGoogle ScholarCrossref
29.
Jones B, Nagin D, Roeder K. A SAS procedure based on mixture models for estimating development trajectories. Sociol Methods Res. 2001;29:374-393. doi:10.1177/0049124101029003005Google ScholarCrossref
30.
Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med. 1989;8(5):551-561. doi:10.1002/sim.4780080504PubMedGoogle ScholarCrossref
31.
Reas ET, Laughlin GA, Kritz-Silverstein D, Barrett-Connor E, McEvoy LK. Moderate, regular alcohol consumption is associated with higher cognitive function in older community-dwelling adults. J Prev Alzheimers Dis. 2016;3(2):105-113.PubMedGoogle Scholar
32.
Maraldi C, Volpato S, Kritchevsky SB, et al. Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study. Arch Intern Med. 2006;166(14):1490-1497. doi:10.1001/archinte.166.14.1490
ArticlePubMedGoogle ScholarCrossref
33.
Logrip ML, Barak S, Warnault V, Ron D. Corticostriatal BDNF and alcohol addiction. Brain Res. 2015;1628(pt A):60-67. doi:10.1016/j.brainres.2015.03.025PubMedGoogle ScholarCrossref
34.
Wilsnack SC, Wilsnack RW. International gender and alcohol research: recent findings and future directions. Alcohol Res Health. 2002;26(4):245-250.PubMedGoogle Scholar

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